Akihide Ohkuchi Selected Research

Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)

1/2021	Short-term prediction of preeclampsia using the sFlt-1/PlGF ratio: a subanalysis of pregnant Japanese women from the PROGNOSIS Asia study.
1/2020	Difficulty of predicting early-onset super-imposed preeclampsia in pregnant women with hemodialysis due to diabetic nephropathy by serum levels of sFlt-1, PlGF, and sEng.
1/2019	Clinical usefulness of serum levels of soluble fms-like tyrosine kinase 1/placental growth factor ratio to rule out preeclampsia in women with new-onset lupus nephritis during pregnancy.
1/2019	Short-Term Prediction of Adverse Outcomes Using the sFlt-1 (Soluble fms-Like Tyrosine Kinase 1)/PlGF (Placental Growth Factor) Ratio in Asian Women With Suspected Preeclampsia.
7/2014	A trio of risk factors for the onset of preeclampsia in the second and early third trimesters.
6/2014	A novel three-step approach for predicting the imminent onset of preeclampsia within 4 weeks after blood sampling at 19-31 weeks of gestation.
12/2013	Onset threshold of the plasma levels of soluble fms-like tyrosine kinase 1/placental growth factor ratio for predicting the imminent onset of preeclampsia within 4 weeks after blood sampling at 19-31 weeks of gestation.
12/2012	Plasma level of hydroxysteroid (17-β) dehydrogenase 1 in the second trimester is an independent risk factor for predicting preeclampsia after adjusting for the effects of mean blood pressure, bilateral notching and plasma level of soluble fms-like tyrosine kinase 1/placental growth factor ratio.
11/2011	Threshold of soluble fms-like tyrosine kinase 1/placental growth factor ratio for the imminent onset of preeclampsia.
11/2009	Effect of recombinant placental growth factor 2 on hypertension induced by full-length mouse soluble fms-like tyrosine kinase 1 adenoviral vector in pregnant mice.

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Akihide Ohkuchi Research Topics

Disease

26	Pre-Eclampsia (Preeclampsia) 01/2022 - 09/2002
13	Hemorrhage 05/2022 - 04/2009
11	Inflammation (Inflammations) 01/2022 - 01/2015
9	Placenta Previa 12/2022 - 01/2003
7	Hypertension (High Blood Pressure) 01/2022 - 03/2006
7	Pregnancy Complications 12/2020 - 01/2015
5	Proteinuria 01/2019 - 02/2009
5	Pregnancy-Induced Hypertension (Hypertension, Pregnancy Induced) 06/2018 - 03/2006
4	Obesity 06/2020 - 03/2006
4	Postpartum Hemorrhage 01/2019 - 04/2013
3	Maternal Obesity 06/2020 - 01/2016
3	Prolapse 03/2017 - 01/2008
2	Premature Birth (Birth, Premature) 12/2022 - 01/2011
2	Postoperative Hemorrhage 12/2022 - 02/2010
2	Thrombocytopenia (Thrombopenia) 01/2019 - 07/2017
2	Abdominal Pain (Pain, Abdominal) 06/2018 - 09/2007
2	Hypoxia (Hypoxemia) 01/2018 - 01/2015
2	Hyperemesis Gravidarum 01/2015 - 08/2009
2	False Aneurysm (Pseudoaneurysm) 09/2014 - 05/2013
1	Prolonged Pregnancy 01/2021
1	Shock 02/2020
1	Hypoglycemia (Reactive Hypoglycemia) 01/2020
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2020
1	Hyperkalemia 01/2020
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2019
1	Hemolysis 01/2019
1	Duodenal Ulcer (Curling's Ulcer) 01/2019
1	Acute fatty liver of pregnancy 01/2019
1	Lupus Nephritis 01/2019
1	Periventricular Leukomalacia (Neonatal Cerebral Leukomalacia) 12/2018
1	Bronchopulmonary Dysplasia 12/2018
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 12/2018
1	Transient Tachypnea of the Newborn 12/2018
1	Perinatal Death 12/2018
1	Adenomyosis 06/2018
1	Fever (Fevers) 06/2018
1	Posterior Leukoencephalopathy Syndrome 01/2018
1	Rheumatoid Arthritis 01/2018
1	Asthma (Bronchial Asthma) 01/2018
1	Stroke (Strokes) 01/2018
1	Liver Diseases (Liver Disease) 07/2017
1	Constipation 03/2016

Drug/Important Bio-Agent (IBA)

15	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2021 - 09/2005
12	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 01/2021 - 09/2005
6	EndoglinIBA 01/2022 - 08/2008
6	InflammasomesIBA 01/2022 - 01/2015
6	CytokinesIBA 06/2020 - 01/2015
4	Ritodrine (Yutopar)FDA Link 01/2020 - 04/2008
4	Interleukin-6 (Interleukin 6)IBA 04/2019 - 01/2015
4	Proteins (Proteins, Gene)FDA Link 07/2016 - 02/2010
3	AntithrombinsIBA 01/2021 - 12/2002
3	Tyrosine (L-Tyrosine)FDA Link 01/2021 - 02/2007
3	Biomarkers (Surrogate Marker)IBA 12/2020 - 02/2012
3	Hemoglobins (Hemoglobin)IBA 02/2020 - 01/2013
3	CreatinineIBA 01/2019 - 07/2016
2	Progesterone FDA LinkGeneric 12/2022 - 01/2021
2	Hemostatics (Antihemorrhagics)IBA 12/2022 - 03/2017
2	Palmitic Acid (Hexadecanoic Acid)IBA 06/2020 - 01/2016
2	InterleukinsIBA 06/2020 - 01/2015
2	Indicators and Reagents (Reagents)IBA 12/2019 - 12/2015
2	Interleukin-8 (Interleukin 8)IBA 04/2019 - 08/2017
2	Oxygen (Dioxygen)IBA 12/2018 - 01/2015
2	C-Reactive ProteinIBA 06/2018 - 01/2011
2	Advanced Glycation End ProductsIBA 08/2017 - 05/2016
2	NucleotidesIBA 11/2015 - 01/2015
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2015 - 01/2015
2	Biological ProductsIBA 07/2014 - 10/2013
2	Oxidoreductases (Dehydrogenase)IBA 12/2012 - 02/2012
1	AlarminsIBA 01/2022
1	LipidsIBA 06/2020
1	Nonesterified Fatty Acids (NEFA)IBA 06/2020
1	Magnesium Sulfate (Sulfate, Magnesium)FDA LinkGeneric 01/2020
1	DNA (Deoxyribonucleic Acid)IBA 12/2019
1	Toll-Like Receptor 9IBA 12/2019
1	Cell-Free Nucleic AcidsIBA 12/2019
1	olive leaf extractIBA 04/2019
1	Transaminases (Aminotransferases)IBA 01/2019
1	EnzymesIBA 01/2019
1	RNA (Ribonucleic Acid)IBA 08/2018
1	Galectin 1 (LGALS1)IBA 01/2018
1	Adenosine Triphosphate (ATP)IBA 01/2018
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2018
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2018
1	Dihydrotachysterol (AT 10)IBA 01/2018
1	Immunoglobulin M (IgM)IBA 01/2018
1	Aspartic Acid (Aspartate)FDA Link 07/2017
1	Lactic Acid (Lactate)FDA LinkGeneric 07/2017
1	HMGB1 Protein (HMG1)IBA 05/2016
1	AmmoniaIBA 03/2016
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2016

Therapy/Procedure

18	Cesarean Section (Caesarean Section) 12/2022 - 01/2003
5	Hysterectomy 05/2022 - 04/2009
3	Sutures (Suture) 12/2022 - 04/2013
3	Dilatation and Curettage 06/2016 - 01/2014
2	Blood Transfusion (Blood Transfusions) 11/2016 - 02/2015
2	Catheters 02/2014 - 04/2013
2	Intravenous Infusions 08/2009 - 04/2008
1	Autologous Blood Transfusion 12/2022
1	Uterine Artery Embolization 02/2020
1	Renal Dialysis (Hemodialysis) 01/2020